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KMID : 0377619630040040269
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Korean Jungang Medical Journal
1963 Volume.4 No. 4 p.269 ~ p.315
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Abstract
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Peripheral blood picture was investigated on rats with average body weight of 150 Gm. after injections of phenylhydrazine, benzol or collargol, or after artificial hemorrhage. Cellular mytotic activity was also studied in the sacrificed animals in a certain period of time following the initial study. The results are summarized in the following.
(I) The number of cellular mytosis in the bone marrow was 16±1. 65 per 2, 000 cells in the control group and 21 ±1. 87 per 2, 000 cells in the group to whom colchicine had been administered 24 hours prior to the sacrifice. It was noted that the cellular mytotic activity was slightly increased in the later group.
(2) The ability of a single or repeated injections of phenylhydrazine, benzol or collargol to produce experimental anemia in rats was reconfirmed by the author. He also found that the degree of anemia was closely correlated with the dosage of the above named agents.
(3) Not only the number of cellular mytosis but that of reticulocytes of the rats with anemia induced by injections of relatively small amount of phenylhydrazine, benzol or collargol were as a rule more than that in the control group. This indicates that the hematopoietic activity is increased in the former group.
(4) The number of cellular mytosis in the bone marrow as well as that of reticuloeytes in the peripheral circulations in rats to whom relatively large amount of phenylhydrazine, benzol or collargol had been administered were found to be decreased from the control level. This indicates that the hematopoietic activity is diminished in the study group.
(5) It was reconfirmed that single or repeated artificial bleeding could cause anemia in rats. It was also found that repeated venotomy in small quantities made rats more anemic than a single venotomy in large amount.
(6) The author found that the number of cellular mytosis in the bone marrow and that of reticulocytes in the peripheral blood of rats upon whom articicial hemorrhage had been performed wre more than that among the control group. He also found that both the number of cellular mytosis in the bone marrow and that of reticulocytes in the peripheral blood in the group who had been made anemic by single venotomy in large quantity were increased more than that in the group who were repeatedly beld in small quantities.
(7) On the basis, as has been described above, that administration of relatively large amount of phenylhydrazine, benzol or collargol can decrease both the number of cellular mytosis in the bone marrow and that of reticulocytes in the peripheral blood in rat; and that the cellular mytosis in the bone marrow and reticulocytes in the peripheral blood are always incrtesesd in numbers in rats to whom artificial bleeding has been performed it is suggested that administration of relatively large amount of phenylhydrazine, benzol or collargol depresses the function of bone marrow directly and profoundly.
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